Predictive value of serum CCL20 and LGR4 for recurrence and metasta-sis of colon cancer after laparoscopic surgery
10.3969/j.issn.1009-9905.2025.01.006
- VernacularTitle:血清CCL20、LGR4对结肠癌腹腔镜术后复发/转移的预测价值
- Author:
Pu QIAO
1
;
Jun LIU
Author Information
1. 西安市中心医院消化外科(陕西 西安 710000)
- Publication Type:Journal Article
- Keywords:
CC motif chemokine ligand 20;
Leucine rich repeat containing G protein-coupled receptor 4;
Colon can-cer;
Laparoscopy;
Recurrence;
Metastasis;
Prediction
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(1):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of serum CC chemokine ligand 20(CCL20)and leucine-rich G protein-coupled receptor 4(LGR4)for recurrence and metastasis in patients with colon cancer after laparoscopic surgery.Methods:A total of 214 patients with colon cancer who underwent laparoscopic surgery for colon cancer from April 2019 to April 2022 were selected as the cancer group,and 214 patients with benign lesions of colon admitted dur-ing the same period were selected as the benign lesion group.According to the results of 2-year follow-up,the patients with colon cancer were divided into recurrent group(66 cases)and non-recurrent group(148 cases).The levels of serum CCL20 and LGR4 were detected by ELISA.ROC curve was used to analyze the predictive value of serum CCL20 and LGR4 for recurrence and metastasis of colon cancer patients after laparoscopic surgery.Multivariate Cox regression analysis of the factors affecting postoperative recurrence and metastasis.Results:The levels of serum CCL20 and LGR4 in the cancer group were significantly lower after operation,but still significantly higher than those in the benign le-sion group(P＜0.05).Serum levels of CCL20 and LGR4 in relapsed group were significantly increased compared with those in non-recurrent group(P＜0.05).There were significant differences in TNM stage,differentiation degree and infil-tration depth between relapse group and non-recurrence group(P＜0.05).Compared with the single prediction,the com-bined detection of serum CCL20(Z=2.733,P=0.006)and LGR4(Z=3.705,P＜0.00)levels significantly increased the AUC in predicting the recurrence and metastasis of colon cancer after laparoscopic surgery.Multivariate Cox regression analy-sis showed that TNM stage,differentiation degree,CCL20 and LGR4 levels were the factors affecting the recurrence and metastasis of colon cancer patients after laparoscopic surgery(P＜0.05).Conclusion:The serum levels of CCL20 and LGR4 increased in patients with colon cancer,and the changes of the levels were closely related to the recurrence and metastasis of colon cancer after laparoscopic surgery.
