The correlation between serum sTREM2 levels and cognitive impairment in patients with cerebral small vessel disease
10.3760/cma.j.cn371468-20241230-00626
- VernacularTitle:脑小血管病患者可溶性髓样细胞触发受体2与认知功能障碍的关联研究
- Author:
Hanfang CUI
1
;
Fangyuan DING
;
Zhixiu XU
;
Qing LI
;
Yifan ZHANG
;
Sen ZHANG
;
Mengke GAO
;
Yuhui CHEN
;
Xiaowen ZHAO
;
Jialu ZHAO
;
Chengbiao LU
;
Shaomin LI
;
Jianhua ZHAO
Author Information
1. 河南医药大学第一附属医院神经内科，河南省神经修复与蛋白修饰重点实验室，河南省老年性痴呆神经修复国际联合实验室，新乡 453100
- Publication Type:Journal Article
- Keywords:
Cerebral small vessel disease;
Deep medullary vein;
Soluble triggering receptor expressed on myeloid cells 2;
Cognitive impairment
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(11):976-982
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2) and cognitive impairment in patients with cerebral small vessel disease (CSVD), and the role of deep medullary vein (DMV) score in this process.Methods:A total of 140 patients with CSVD admitted to the Department of Neurology, the First Affiliated Hospital of Henan Medical University from December 2022 to August 2024 were selected as the research objects. The basic data statistics, head magnetic resonance imaging examination, cognitive function assessment, serum sTREM2 detection and DMV score were performed. All data were analyzed by SPSS 29.0 software and GraphPad Prism 10.0 software packages. Logistic regression model was used to explore the influencing factors of cognitive impairment. Structural equation model was used to analyze the mediating effect of DMV score on the association between serum sTREM2 and cognitive impairment. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of serum sTREM2 level and DMV score for cognitive impairment in CSVD patients.Results:Serum sTREM2 level ( B=0.017, OR=1.017, 95% CI=1.003-1.031), DMV score ( B=0.375, OR=1.455, 95% CI=1.175-1.802) and years of education ( B=-0.248, OR=0.780, 95% CI=0.635-0.958) were risk factors for cognitive impairment (all P<0.05). sTREM2 not only directly affected cognitive function, but also indirectly affected cognitive function through DMV score. The direct effect (effect size=-0.022) and mediating effect (effect size=-0.007) accounted for 75.9% and 24.1% of the total effect (effect size=-0.029), respectively. The areas under the ROC curve of serum sTREM2 level, DMV score, and their combination for predicting cognitive impairment in CSVD patients were 0.880, 0.891, and 0.910, respectively (all P<0.001). Conclusion:Serum sTREM2 not only directly affects the cognitive function of patients with cerebral small vessel disease, but also indirectly affects cognitive function through DMV score. The combination of serum sTREM2 levels and DMV score has high predictive value for the risk of CSVD-related cognitive impairment.
