Endometrial Carcinoma Arising in Endometrial Polyps:a Clinicopathologic Review of 38 Cases
- VernacularTitle:子宫内膜息肉恶变38例临床病理特征分析
- Author:
Wei XU
1
;
Xianglian WANG
1
;
Xing CHEN
1
;
Lin ZHANG
1
;
Wenjun CHENG
1
Author Information
1. 南京医科大学第一附属医院妇科,江苏 南京 210029
- Publication Type:Journal Article
- Keywords:
Endometrial tumor;
Endometrial polyp;
Malignant transformation;
Tumor arising;
Clinicopathology
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features,treatment and prognosis of endometrial carcinoma arising in endometrial polyps(EPs).Methods:Thirty-eight cases of endometrial carcinoma arising in EPs were collected in the First Affiliated Hospital of Nanjing Medical University from January 2010 to December 2021.The clinical data,pathological characteristics,and follow-up information were retrospectively analyzed from three dimensions:tumor histological type,the menopausal status of the patients and the scope of malignant le-sions.Results:①In terms of tumor histological type,uterine endometrioid carcinoma 33 cases(86.8%)and uter-ine serous carcinoma 50 cases(13.2%),the mean age of patients with endometrioid carcinoma arising from EPs was significantly lower than that of patients with serous carcinoma arising from EPs(53.3±10.0 years vs.63.4±10.3 years,P=0.043).②In terms of menopausal status,endometrioid carcinoma progressed from atypical poly-poid adenomyoma(APA)accounted for 55.6%(10/18)and 5.0%(1/20)in the pre-and post-menopausal group,respectively(P=0.001).The rate of adjuvant therapy was significantly lower in premenopausal patients than in postmenopausal patients(16.7%vs.50.0%,P=0.043).③There were no significant differences in pa-tients age,menopausal status,BMI,comorbidities,abnormal uterine bleeding,maximum diameter of EP,tumor stage,grade,treatment or recurrence rate between cases with tumors confined and unconfined to EPs.Conclu-sions:Endometrioid and serous carcinomas progressed from EPs were more common in perimenopausal and postmenopausal patients,respectively.Malignancies derived from APA contributed to almost half of EP-arising carcinomas in premenopausal women,with a higher degree of differentiation and a low rate of postoperative adju-vant therapy.
