Cerebellum and cognitive dysfunction in Alzheimer's disease

VernacularTitle:小脑与阿尔茨海默病认知障碍
Author: Jiayun WU ¹ ; Zhi GENG ¹ ; Xingqi WU ¹ ; Ling WEI ¹
Author Information

1. 安徽医科大学第一附属医院神经内科，合肥　230022
Publication Type:Journal Article
Keywords: Cerebellum; Alzheimer's disease; Cognitive dysfunction; Treatment strategy
From: Chinese Journal of Behavioral Medicine and Brain Science 2025;34(9):852-857
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is a progressively worsening neurodegenerative disorder primarily characterized by cognitive dysfunction, which increasingly impairs patients' quality of life as the condition worsened.Recent studies have found that the cerebellum not only plays a crucial role in motor coordination but also is key in learning, memory and executive functions.However, the mechanisms of the cerebellum influences cognitive function in AD patients remain unclear, and further research is needed to elucidate these processes in greater depth.This article reviews the latest research advances on the cerebellum and AD-related cognitive dysfunction, and explores the role of the cerebellum in the pathogenesis, clinical manifestations, and potential treatment strategies for AD, in order to provide valuable insights for future investigations into the pathological mechanisms and clinical therapies of AD.