Altered patterns of interhemispheric functional connectivity in the cerebral cortex connected via the corpus callosum in Alzheimer's disease
10.3969/j.issn.1005-202X.2025.11.005
- VernacularTitle:阿尔茨海默病经胼胝体相连大脑皮质的跨半球功能连接改变模式
- Author:
Zheyu LI
1
;
Yifan SHEN
;
Renren LI
;
Chenxi PAN
;
Wei ZHANG
;
Zhihao XU
;
Qiurong YU
;
Dazhi YIN
;
Mingxia FAN
;
Yunxia LI
;
Ruipeng NING
Author Information
1. 华东师范大学物理与电子科学学院上海市磁共振重点实验室,上海 200062;华东师范大学医学磁共振与分子影像技术研究院,上海 200062
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
mild cognitive impairment;
dementia;
corpus callosum;
resting-state functional magnetic resonance imaging;
functional connectivity
- From:
Chinese Journal of Medical Physics
2025;42(11):1434-1444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate alterations in interhemispheric functional connectivity(FC)in the cerebral cortices connected via the corpus callosum in patients with Alzheimer's disease(AD),and to explore their relationships with cognitive function and activities of daily living.Methods Resting-state functional magnetic resonance imaging data were collected from 28 patients with Alzheimer's dementia(d-AD),47 patients with mild cognitive impairment(MCI),and 37 healthy controls(HC).Using a trancallosal tract template,32 pairs of homologous cortical brain regions directly connected to 32 subregions of the corpus callosum were selected as regions of interest for interhemispheric FC analysis.Further correlation analyses were performed between FC values in patient groups and their scores on the Montreal Cognitive Assessment-Basic(MoCA-B)Scale and the Activities of Daily Living(ADL)Scale.Results Compared with HC group,both MCI and d-AD groups exhibited hyperconnectivity(significantly increased FC)in interhemispheric non-homologous brain regions.Specifically,hyperconnectivity in the MCI group was scattered across the frontal,parietal,temporal,and occipital lobes,while in the d-AD group,it was concentrated within the precentral and postcentral gyri.Notably,hyperconnectivity involving the prefrontal and occipital lobes in the MCI group showed significant declines in the d-AD group.The interhemispheric homologous FC in the d-AD group reduced more significantly than the MCI group.Additionally,in the d-AD group,2 interhemispheric FC within the prefrontal lobe(between the bilateral orbital parts of the inferior frontal gyrus,and between the left medial frontal gyrus and the right middle frontal gyrus)were correlated with MoCA-B scores,and 2 FC(between the bilateral middle occipital gyri,and between the left inferior parietal lobule and the right middle frontal gyrus)were correlated with ADL scores.Conclusion MCI and d-AD exhibit distinct patterns of interhemispheric FC alterations,and the interhemispheric FC changes in AD patients are non-progressive.The close relationships between interhemispheric homologous/non-homologous FC and MoCA-B/ADL scores in d-AD patients provide an objective basis and reference for clinical neuromodulation.
