Correlation between excessive daytime sleepiness and clinical features as well as inflammatory cytokines in adolescents with major depressive disorder
10.3760/cma.j.cn371468-20250408-00140
- VernacularTitle:青少年抑郁障碍患者日间嗜睡与临床特征及炎性细胞因子的相关性
- Author:
Liping ZHAO
1
;
Lewei LIU
;
Lili ZHAO
;
Daming MO
;
Huanzhong LIU
Author Information
1. 淮北职业技术学院医学系，淮北 235000
- Publication Type:Journal Article
- Keywords:
Major depressive disorder;
Excessive daytime sleepiness;
Clinical features;
Inflammatory cytokines;
Adolescents
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(9):816-822
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation of excessive daytime sleepiness (EDS)with clinical features as well as inflammatory cytokines in adolescents with major depressive disorder.Methods:From January to December 2021, a total of 164 adolescents with major depressive disorder were included in the psychiatry departments of two hospitals in Anhui province, China, and divided into the EDS group ( n=70) and the non-EDS group ( n=94) according to whether or not they were accompanied by EDS. The center for epidemiological studies depression scale (CES-D) and the positive and negative suicidal ideation scale (PANSI) were used to assess patients' depressive symptoms severity and suicidal ideation levels, respectively. Additionally, plasma levels of inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-10, IL-17A, and tumour necrosis factor-α (TNF-α) were measured using the MSD ultrasensitive multifactor electrochemiluminescence analyzer. Statistical analysis were performed using SPSS 23.0 software, and independent influences of EDS were analyzed by Logistic stepwise regression. Results:The prevalence of EDS was 42.7%(70/164) in adolescents with major depressive disorder. In univariate analysis, patients in the EDS group had higher body mass index (BMI), CES-D total score, PANSI total score, IL-1β (Log) and IL-6 (Log) compared to the non-EDS group (all P<0.05). Logistic stepwise regression analysis showed that BMI ( OR=1.094, 95% CI=1.007-1.189, P=0.033), CES-D total score ( OR=1.043, 95% CI=1.012-1.075, P=0.007), and IL-1β (Log) ( OR=3.868, 95% CI=1.484-10.079, P=0.006) were independent influencing factors of EDS in adolescents with major depressive disorder. Conclusions:The risk of EDS in adolescents with major depressive disorder is relatively high, and EDS may be closely related to BMI, depression severity, suicidal ideation and IL-1β level.
