Fabrication and research of gelatin-based tissue mimicking material phantom with wall-less blood vessels for ultrasound applications
10.3969/j.issn.1005-202X.2025.11.016
- VernacularTitle:基于明胶含无壁血管的超声仿组织材料模体的制备及研究
- Author:
Hongwei LI
1
;
Peikai WU
;
Zixu XU
;
Xinye NI
Author Information
1. 南京医科大学附属常州第二人民医院放疗科,江苏 常州 213003;江苏省医学物理工程研究中心/南京医科大学医学物理研究中心/常州市医学物理重点实验室,江苏 常州 213003;四川省通江县人民医院放疗中心,四川 巴中 636700;四川省肿瘤医院放疗中心,四川 成都 610041
- Publication Type:Journal Article
- Keywords:
Doppler ultrasound;
tissue mimicking material;
hemodynamic parameter;
blood mimicking fluid
- From:
Chinese Journal of Medical Physics
2025;42(11):1507-1513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To fabricate wall-less vascular tissue mimicking materials(TMM)with different tube diameters that match the hemodynamic parameters of human carotid arteries,and to investigate their hemodynamic characteristics.Methods TMM with different diameters and blood mimicking fluids containing scattering particles were fabricated.The variation laws of hemodynamic parameters under different flow velocities and TMM phantom diameters were verified.Key hemodynamic parameters including peak systolic velocity(PSV),end-diastolic velocity(EDV),and resistance index were measured using Doppler ultrasound,and their clinical application value in carotid artery diseases was evaluated.Results The fabricated samples exhibited a sound velocity of(1506.2±0.1)m/s and an attenuation of(0.76±0.01)dB/cm,and the vascular diameters were 4.0 and 6.0 mm,which corresponded to the normal clinical range of the external and internal carotid arteries,respectively.For the 4.0 mm TMM,both PSV and EDV were linearly correlated with flow velocity(R2=0.77,P<0.001;R2=0.74,P=0.001),and Pearson correlation analysis confirmed strong positive correlations(r=0.89,95%CI:0.82-0.93;r=0.94,95%CI:0.90-0.97,all P<0.001).For the 6.0 mm TMM,PSV and EDV also demonstrated significant linear correlations with flow velocity(R2=0.70,P=0.001;R2=0.61,P=0.005),with Pearson correlation analysis revealing strong positive correlations(r=0.86,95%CI:0.78-0.91;r=0.79,95%CI:0.68-0.87).All the data were consistent with hemodynamic parameters and followed the variation law of hemodynamic parameters.Conclusion The fabricated TMM and blood mimicking fluids meet the requirements for clinical ultrasound research on hemodynamics,and their material ratios can be used as a reference for the subsequent researches with diverse objectives.
