Latent classes of behavioural and psychological symptoms in patients with Alzheimer's disease and the influencing factors
10.3969/j.issn.1671-8283.2025.10.001
- VernacularTitle:阿尔兹海默病患者精神行为症状的潜在类别及其影响因素
- Author:
Xi ZHANG
1
;
Chunxia WANG
1
;
Li YU
1
;
Ziying ZOU
1
;
Xiaojiao GONG
1
Author Information
1. 南昌大学第一附属医院神经内科,江西 南昌,330000
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
dementia;
behavioural and psychological symptoms;
latent class analysis;
cross-sectional study
- From:
Modern Clinical Nursing
2025;24(10):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore latent classes of behavioural and psychological symptoms in the patients with Alzheimer's disease(AD)and to identify the factors influencing the latent classes and provide a basis for fomulating personalized nursing measures.Methods Convenience sampling was employed to recruit 361 AD inpatients from our hospital between November 2023 and May 2024 for this cross-sectional study.A general data questionnaire,the neuropsychiatric inventory questionnaire,Monteria cognitive assessment scale,activity of daily life scale,and mini-nutritional assessment scale were used in the survey.Latent class analysis was conducted to analyse the data acquired from the survey.Univariate analysis and multiple Logistic regression analysis were used to identify the factors influencing latent classes.Results Toally 346 patients finished the study.It was found that a 72.5%of AD patients developed behavioural and psychological symptoms.The symptoms were categorised into three classes:low symptom-apathy,middle symptom-emotional disturbance and high symptom-behaviour disorder.The course of disease,cognitive function,daily living ability and nutritional status were identified as the factors that influenced the latent classes(all P<0.05).Conclusion AD patients with low cognitive function,poor daily living ability,malnutrition and a course of disease over 5 years are at high risks of behavioural and psychological symptoms which are heterogeneous.Care providers are advised to propose personalised care strategies to improve the behavioural and psychological symptoms.
