Application of optical coherence tomography angiography in neurodegenerative diseases
10.3760/cma.j.cn371468-20250219-00061
- VernacularTitle:光学相干断层扫描血管成像在神经退行性疾病中的应用
- Author:
Chao WANG
1
;
Jiaqi WU
;
Yueshan ZHAO
;
Qishuo YANG
;
Yan WANG
;
Peiyuan LYU
Author Information
1. 华北理工大学研究生院，唐山 063000
- Publication Type:Journal Article
- Keywords:
Optical coherence tomography angiography;
Neurodegenerative diseases;
Retinal vessels;
Diagnosis;
Assessment
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(8):763-768
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are a class of nervous system disorders characterized by delayed onset and selective neuronal dysfunction, which are closely associated with aging.Given the challenges associated with early detection and the irreversible nature of the condition, the pursuit of specific biomarkers has emerged as a critical component of disease prevention strategies.Optical coherence tomography angiography (OCTA) generates images which exhibit near-histological resolution without the requirement for contrast agent injection, demonstrating superior sensitivity compared to fundus photography. OCTA has the ability to identify and evaluate neurodegenerative diseases via the quantitative analysis of retinal parameters. The OCTA of the retina and choroid has been verified as a highly sensitive instrument for detecting microvascular abnormalities in both ocular and systemic retinal disorders. This review focuses on the application of OCTA in various neurodegenerative diseases, such as Alzheimer′s disease, Parkinson disease, Huntington′s disease, amyotrophic lateral sclerosis and Wolfram syndrome, with the aim of providing a reference for the early diagnosis and prevention of neurodegenerative diseases.
