Cerebellar synaptic plasticity and addictive behaviors
10.3760/cma.j.cn371468-20250114-00024
- VernacularTitle:小脑突触可塑性与成瘾行为
- Author:
Wei LI
1
;
Shuyuan YANG
1
;
Jingping SHI
1
Author Information
1. 南京医科大学附属脑科医院神经内科，南京 210029
- Publication Type:Journal Article
- Keywords:
Cerebellum;
Synaptic plasticity;
Addiction;
Neural mechanism;
Reward circuitry;
Biomarker
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(8):758-762
- CountryChina
- Language:Chinese
-
Abstract:
The cerebellum plays a critical role not only in motor control but also in reward processing, emotional regulation, and addictive behaviors.Addictive behaviors alter the cerebellum’s neurotransmitter systems and synaptic connections, leading to dysfunction and reinforcing the persistence of addiction.This review summarizes the anatomical and functional foundations of the cerebellum in the reward circuitry and explores how cerebellar synaptic plasticity influences brain function in both substance and behavioral addictions. Furthermore, the potential role of the cerebellum in the progress of addiction and its clinical application prospects in addiction treatment are also discussed.
