The expressions of CD62P,CD40L,and Rev-erbα after ischemic stroke on different onset times
10.3969/j.issn.1006-7795.2025.01.006
- VernacularTitle:CD62P、CD40L及节律核受体Rev-erbα在缺血性脑卒中不同发病时间的表达
- Author:
Yinping WANG
1
;
Cancan MENG
;
Wenjuan WU
;
Zhitang YANG
Author Information
1. 河北工程大学临床医学院,河北邯郸 056000
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
platelet activation;
CD62P;
CD40L;
rhythm nuclear receptor Rev-erbα
- From:
Journal of Capital Medical University
2025;46(1):34-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of platelet activating factor and rhythm nuclear receptor Rev-erbα in patients after ischemic stroke on different onset times.Methods A total of 158 patients after ischemic stroke admitted from June 2022 to May 2023 were divided into four groups according to the onset time T1(0-6 o'clock),T2(6-12 o'clock),T3(12-18 o'clock),and T4(18-24 o'clock).Matched to the ischemic stroke groups,126 patients hospitalized at the same time with non-ischemic stroke were divided into four groups.General data and serum samples of the subjects were collected,and the expression levels of CD62P,CD40L and Rev-erbα were detected with enzyme-linked immunosorbent assay(ELISA).Results The expressions of platelet activating factor CD62P,tumor necrosis factor CD40L,and rhythm nuclear receptor Rev-erbα in T2 group after ischemic stroke were significantly higher than that in the other groups(P＜0.05),whilst no significant difference were observed in other three groups(P＞0.05).The expression of CD62P,CD40L and rev-erbα in ischemic stroke groups were significantly higher than that in control groups.Conclusion The expression levels of the rhythm nuclear receptor Rev-erbα,CD62P,and CD40L in ischemic stroke groups is higher than that in control groups,and the expression of these cytokines is more significant in T2 group(i.e.early in the morning)than other time slot.On the other hand,the expressions of CD62P and CD40L are consistent with Rev-erbα on the time slots,indicating a clear correlation.It is indicated Rev-erbα and platelet activation play a key role on attacking of ischemic stroke.
