Role of lateral habenula and its associated neural circuitry projections in pain regulation
10.3760/cma.j.cn371468-20250303-00081
- VernacularTitle:外侧僵核及其投射神经环路在疼痛调控中的作用
- Author:
Yanjuan REN
1
;
Dongxu WANG
;
Ya CAO
;
Yuxuan ZHANG
;
Lu QIAN
;
Danru WU
;
Zhonghua LI
;
Ling ZHANG
;
Yu SHEN
;
He LIU
Author Information
1. 徐州医科大学麻醉学院，徐州 221004
- Publication Type:Journal Article
- Keywords:
Lateral habenula;
Pain;
Neural circuit;
Neuromodulation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(5):465-469
- CountryChina
- Language:Chinese
-
Abstract:
Pain modulation encompasses a complex neurobiological process, in which the lateral habenula (LHb) plays a crucial role in integrating, regulating and modulating pain signals. It is also involved in pain-related memory functions associated with perception, transmission and regulation of pain. Furthermore, the LHb collaborates with structures such as the spinal dorsal horn, forebrain, and amygdala to form an essential neural circuit that contributes to sensitization, development of tolerance, and adaptation processes related to pain. However, there remains limited understanding regarding the specific roles and interactions among different neuron subtypes within the LHb concerning pain regulation. Additionally, further investigation is warranted to explore functional changes and plasticity within both the LHb and its associated neural circuits in chronic pain models. Future research endeavors should utilize advanced neuroimaging techniques alongside optogenetics and gene editing technologies to elucidate intricate neural circuits, cellular architecture, and molecular mechanisms governing LHb function in pain regulation. In conclusion, this paper aims to comprehensively review existing literature on the involvement of the LHb and its neural circuits in modulating pain, thereby enhancing our understanding of their neurobiological mechanisms while providing novel targets for precise therapeutic strategies aimed at alleviating pain.
