Ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis:one case report
10.3969/j.issn.1672-8467.2025.06.018
- VernacularTitle:卵巢畸胎瘤相关抗N-甲基-D-天冬氨酸受体脑炎1例报告
- Author:
Qiao-ying LYU
1
;
Yi-qin WANG
;
Xue-zhen LUO
Author Information
1. 复旦大学附属妇产科医院妇科 上海 200011;上海市女性生殖内分泌相关疾病重点实验室 上海 200011
- Publication Type:Journal Article
- Keywords:
anti-N-methyl-D-aspartate receptor encephalitis;
ovarian teratoma;
multidisciplinary collaboration;
immunotherapy;
prognosis
- From:
Fudan University Journal of Medical Sciences
2025;52(6):908-912
- CountryChina
- Language:Chinese
-
Abstract:
A 21-year-old unmarried female visited Obstetrics and Gynecology Hospital,Fudan University with the chief complaint,memory decline for more than 20 days and discovery of a pelvic mass for more than 10 days.Through systematic examination,she was diagnosed with teratoma-associated anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis.The patient underwent bilateral ovarian teratoma enucleation,and postoperative pathology revealed immature teratoma grade Ⅰ in the left ovary and mature teratoma in the right ovary.Perioperative combined immunotherapy significantly improved her neuropsychiatric symptoms.The diagnosis and treatment of ovarian teratoma-associated anti-NMDAR encephalitis require multidisciplinary collaboration,with accurate diagnosis,timely surgical resection within 1 month,and early initiation of immunotherapy being critical factors for improving prognosis.Clinicians should remain vigilant to avoid missed or misdiagnosed cases,as this condition can lead to severe outcomes.
