Research progress on siRNA in the treatment of lung injury
10.3969/j.issn.1672-8467.2025.06.014
- VernacularTitle:siRNA在肺损伤治疗中的研究进展
- Author:
Fu-li LIU
1
;
Han-bing HU
1
;
Jie SHEN
1
Author Information
1. 复旦大学附属金山医院急危重病中心 上海 201508;复旦大学化学伤害急危重病医学研究中心 上海 201508;上海市卫生健康委员会化学伤害急危重病医学重点实验室 上海 201508
- Publication Type:Journal Article
- Keywords:
lung injury;
small interfering RNA(siRNA);
therapy;
gene expression regulation
- From:
Fudan University Journal of Medical Sciences
2025;52(6):883-891
- CountryChina
- Language:Chinese
-
Abstract:
The lung is a vital organ that is in direct contact with the external environment.It is extremely susceptible to a variety of exogenous factors,which can trigger a series of inflammatory responses and lead to varying degrees of tissue damage.With the development of genetic engineering technology,silencing specific target genes through RNA interference has become a new strategy for the treatment of lung injury.Small interfering RNA(siRNA)is a crucial role in RNA interference that can bind to the target gene through base complementary pairing to inhibit its expression,thereby producing a corresponding regulatory effect.Due to its specific targeting and low biological toxicity,siRNA is gradually becoming an ideal tool for the treatment of lung injury and other lung diseases.This article reviews the mechanism of action of siRNA and its application progress and research status in the treatment of lung injury.
