Research progress of Calpain in fibrotic diseases
10.3969/j.issn.1672-8467.2025.06.016
- VernacularTitle:钙蛋白酶在纤维化疾病中的研究进展
- Author:
Dian-yu CAO
1
;
Qiang WANG
1
Author Information
1. 复旦大学附属中山医院皮肤科 上海 200032
- Publication Type:Journal Article
- Keywords:
fibrosis;
pathophysiology;
Calpain;
inhibitor
- From:
Fudan University Journal of Medical Sciences
2025;52(6):897-902
- CountryChina
- Language:Chinese
-
Abstract:
Calpain-mediated fibrosis,a physiological tissue repair process that almost occurs in most of tissues and organs,is closely related to multiple cellular pathways and is widely involved in the progression of diseases.It is believed that the pro-and anti-fibrotic systems are dynamic regulated in vivo,so pathological organ fibrosis still may be controlled and even reversed.This review summarizes the latest researches on the role of Calpain family in different organ fibrosis and the intervention of Calpain inhibitor in fibrosis progression,aiming to providing a reference for the research of Calpain family in fibrotic diseases context.
