Biological Functions of Sesamol and Its Role in Antitumor Activity
10.13865/j.cnki.cjbmb.2024.10.1196
- VernacularTitle:芝麻酚的生物学功能及其在抗肿瘤中作用
- Author:
Ya-Hui CAI
1
;
Yan-Ping LI
;
Xiao-Nan WEI
Author Information
1. 济宁医学院临床医学院,山东济宁 272067
- Publication Type:Journal Article
- Keywords:
sesamol;
polyphenols;
tumor therapy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(1):105-111
- CountryChina
- Language:Chinese
-
Abstract:
Sesamol is a fat-soluble natural polyphenol compound found in sesame seeds and sesame oil,which is widely used in food.Sesamol can effectively scavenge free radicals in the body,reduce oxidative stress,and protect cells from damage,therefore it plays an important role in the prevention of cardiovas-cular disease,cancer and neurodegenerative diseases.It has been widely studied for its various pharma-cological functions such as antioxidant,antibacterial,anti-inflammatory,neuroprotective,cardioprotec-tive,immunomodulatory and antitumor.In recent years,sesamol,as a safe and non-toxic chemical sub-stance,has received extensive attention in the field of tumor research and is expected to be used as a clinical drug for tumor therapy in the future.In this paper,through the collection and analysis of relevant literature on sesamol at home and abroad,we reviewed the biological functions of sesamol in antioxidant,anti-inflammatory,antibacterial,regulating energy metabolism,cardiovascular protection,and neuropro-tection,etc.as well as its mechanism of action.Furthermore,this review also focused on the role of ses-amol in regulating cellular energy metabolism,inducing apoptosis,blocking the cell cycle,modifying ep-igenetic modifications,promoting cellular autophagy,inhibiting angiogenesis,reducing the tolerance of chemotherapeutic drugs,and so on.In addition,this paper also focused on the anti-tumor effects of sesa-mol by regulating cell energy metabolism,inducing cell apoptosis,modulating epigenetic modification,promoting cell autophagy,inhibiting angiogenesis,and reducing the tolerance of chemotherapeutic drugs,etc.This review aims to provide a new theoretical basis for the development of tumor therapeutic drugs.
