Regulation of ENO1 by Long Non-coding RNA
10.13865/j.cnki.cjbmb.2024.10.1315
- VernacularTitle:长非编码RNA对α-烯醇化酶的调控作用
- Author:
Chun-Yuan ZHU
1
;
Fei LI
;
Yu-Ping WANG
Author Information
1. 兰州大学第二临床医学院,兰州 730000
- Publication Type:Journal Article
- Keywords:
alpha-enolase 1(ENO1);
glycolysis;
long non-coding RNA(lncRNA);
tumor
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(1):89-98
- CountryChina
- Language:Chinese
-
Abstract:
Alpha-enolase 1(ENO1)is a multifunctional protein that serves as a glycolysis enzyme,a plasminogen receptor,and a DNA-binding protein,playing a critical role in tumorigenesis and progres-sion.Long non-coding RNAs(lncRNAs)are crucial regulators of chromatin structure and gene expres-sion.Accumulated data have unveiled that lncRNAs regulate ENO1 through multiple pathways.In the nucleus,lncRNAs act on the ENO1 promoter to regulate its transcription.In the cytoplasm,lncRNAs af-fect ENO1 translation by acting directly or indirectly with ENO1 mRNA and by adsorbing small ribonucle-ic acids as sponges.Additionally,in the cytoplasm,lncRNAs influence the stability,enzyme activity,and other functions of ENO1 by directly binding to the ENO1 protein and acting as scaffold molecules to form a polymer with ENO1.In tumors,the abnormal expression of lncRNA regulates the overexpression and function of ENO1,promoting the proliferation and metastasis of tumor cells.There is currently some knowledge on the interaction between lncRNA and ENO1,and further investigation is needed to reveal the specific molecular mechanisms and biological functions,as well as the potential applications of ln-cRNA in clinical treatment.Here,we review the regulatory role of lncRNAs on ENO1,focusing on 16 i-dentified lncRNAs that regulate ENO1.Understanding the regulatory effects of lncRNAs on ENO1 will enhance our knowledge of the regulatory network involving ENO1 in tumor cells and may reveal new tar-gets for cancer treatment.
