Combined effect of coronary artery calcification score progression and sleep structure on major adverse cardiovascular events
10.3969/j.issn.1002-1671.2025.02.010
- VernacularTitle:冠状动脉钙化积分进展和睡眠结构对主要不良心血管事件的综合影响
- Author:
Jiali LIU
1
;
Shuangxin LI
1
;
Wenxuan YANG
1
;
Jun SHU
1
;
Xugang WANG
1
;
Yuanqiang ZHU
1
;
Minwen ZHENG
1
Author Information
1. 空军军医大学西京医院放射科,陕西 西安 710032
- Publication Type:Journal Article
- Keywords:
coronary artery calcification score;
rapid eye movement sleep;
major adverse cardiovascular events;
sleep structure
- From:
Journal of Practical Radiology
2025;41(2):221-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the combined effect of coronary artery calcification score(CACS)progression and sleep structure on major adverse cardiovascular events(MACE).Methods Data from the Multi-Ethnic Study of Atherosclerosis(MESA)were used to analyze participants and assess the interaction impact of CACS progression and different sleep stages on predicting MACE.Polysomnography(PSG)record provide an objective measure of sleep structure.Results The results of this study confirmed the dose-response relationship between CACS progression and MACE.ΔCACS 10-99 hazard ratio(HR)was 6.913(P＜0.001),ΔC ACS 100-199 HR was 22.098(P＜0.001),ΔCACS＞200 HR was 20.608(P＜0.001),reinforcing the notion that the rate of CACS development significantly affects cardiovascular risk.In addition,the study found that participants who showed lower rapid eye movement(REM)sleep and progression of CACS had the greatest risk of developing MACE,while participants who showed higher REM sleep but no progression of CACS had the lowest risk of developing MACE(P＜0.001).Conclusion Decreased REM sleep increases the risk of MACE in CACS patients,and maintaining adequate REM sleep may reduce this risk,emphasizing the protective effect of REM sleep on cardiovascular disease.
