Clinical significance of detection of interleukin-6,C reactive protein,and eutrophic-to-lymphocyte ratio alone and in combination in the prognosis assessment of severe pneumonia
10.13431/j.cnki.immunol.j.20250096
- VernacularTitle:IL-6、CRP、NLR联合检测对重症肺炎预后评估的价值
- Author:
Ruohan LI
1
;
Niwen HUANG
;
Yaqiong DONG
Author Information
1. 贵州医科大学临床医学院,贵阳 550004
- Publication Type:Journal Article
- Keywords:
severe pneumonia;
interleukin-6;
C reactive protein;
neutrophil-to-lymphocyte ratio;
severe pneumonia;
prognosis assessment
- From:
Immunological Journal
2025;41(10):689-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application value of detection of interleukin-6(IL-6),C reactive protein(CRP),and neutrophic-to-lymphocyte ratio(NLR)alone and in combination in the prognosis assessment of severe pneumonia(SP).Methods A total of 81 patients with SP admitted from December 2022 to December 2023 were selected as the research subjects.According to the discharge outcomes of the patients,they were divided into the survival group(n=62)and the death group(n=19).The general clinical data at admission and laboratory parameters of the two groups were collected and compared.The receiver operating characteristic(ROC)curve was used to analyze the value of serum IL-6,CRP and NLR detection in the prognosis assessment of SP.Results At admission,the pulse of the death group was higher than that of the survival group,while the systolic blood pressure(SBP)was lower than that of the survival group(P<0.05,P<0.01).The incidence of chest tightness in the death group at admission was significant higher than that in the survival group(P<0.05).Compared with the survival group,the number of lymphocyte counts and albumin levels in the death group were lower,while the percentage of neutrophils,NLR and procalcitonin were higher than those in the survival group(P<0.05,P<0.01).ROC curve analysis showed that the area under the curve(AUC)for predicting poor prognosis of SP by the combined detection of IL-6,CRP and NLR was 0.75,which was higher than that predicted by each indicator alone.Conclusion Compared with the detection of IL-6,CRP and NLR alone,the combined detection of the three has a more significant value in predicting the risk of death in patients with SP.It suggests that clinicians should promptly,comprehensively and dynamically monitor the above infection indicators during diagnosis and treatment,and take prompt and effective intervention measures to reduce the mortality rate of patients.
