Hypoxia inducible factor 1 and depressive disorder
- VernacularTitle:缺氧诱导因子-1与抑郁症
- Author:
Lan WU
1
;
Yinping XIE
1
;
Hailong GE
1
;
Chen LI
1
;
Junjie HUANG
1
;
Lujia SI
1
;
Ling XIAO
1
;
Gaohua WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Depressive disorder; Hypoxia inducible factor 1 (HIF-1); Neuronal plasticity; Neuroinflammation
- From: Chinese Journal of Behavioral Medicine and Brain Science 2025;34(4):375-379
- CountryChina
- Language:Chinese
- Abstract: Depressive disorder is a kind of mental disorder characterized by persistent and significant depressed mood, with complex etiology and high recurrence rate. At present, more precise and effective diagnostic and therapeutic approaches are still required. Increasing evidence suggests that hypoxia inducible factor-1 (HIF-1) and related pathways are involved in regulating the development and recovery of depression. HIF-1 enhances neuroplasticity, mitigates neuroinflammatory responses, alleviates oxidative stress, and modulates brain energy metabolism by influencing specific molecules associated with depression. This paper reviews pertinent domestic and international studies, examine the potential mechanisms of HIF-1 in the pathogenesis and progression of depression, and explore antidepressant treatment strategies targeting the HIF-1 signaling pathway. This article provides novel insights into elucidating the pathogenesis of depression and developing innovative therapeutic approaches.
