The Role of Peroxisome Proliferator-activated Receptor(PPAR)-mediated Energy Metabolism in Kidney Diseases
10.13865/j.cnki.cjbmb.2024.11.1176
- VernacularTitle:过氧化物酶体增殖物激活受体介导的能量代谢重塑在肾疾病中的作用
- Author:
Qi-Hui DAI
1
;
Meng YANG
1
;
Xin-Guang LIU
1
Author Information
1. 广东省医学免疫与分子诊断重点实验室,广东医科大学衰老研究所,广东医科大学生物化学与分子生物学研究所,广东医科大学医学技术学院,广东东莞 523808
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-activated receptor(PPAR);
kidney;
energy metabolism;
kidney diseases
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(2):238-248
- CountryChina
- Language:Chinese
-
Abstract:
With the prevalence of kidney disease continues to rise,it has become a serious global public health issue that significantly impacts patients'quality of life.The complex pathogenesis of kidney disea-ses presents challenges for its prevention and treatment.Research has shown that imbalances in metabolic homeostasis often affect kidney function,leading to renal damage.Peroxisome proliferator-activated re-ceptors(PPARs),as transcription factors activated by endogenous ligands,play a crucial role in regula-ting metabolic molecular networks,particularly in oxidative phosphorylation,lipid metabolism,and glu-cose metabolism.Activating PPARs can improve mitochondrial damage,promote tatty acid breakdown,and alleviate insulin resistance,thereby restoring renal metabolic function and mitigating kidney damage.Although various small-molecule drugs that activate PPARs have been developed,adverse reactions have been observed during clinical trials.Currently,there is still a lack of safe and effective treatment options for kidney diseases.A detailed analysis of the molecular mechanisms by which the PPAR family regulates renal cell energy metabolism,as well as the search for and development of new small-molecule drugs tar-geting PPARs and their regulated downstream metabolic pathways,is of significant importance for under-standing and treating kidney diseases.On the other hand,clarifying the metabolic changes during the progression of different kidney diseases and applying targeted PPAR-based drugs or strategies for their treatment is particularly important.Here we summarize how PPAR family members regulate target gene transcription and their roles in the remodeling of oxidative phosphorylation and lipid/glucose metabolism,as well as the impact of changes in PPAR expression or activity on acute and chronic kidney diseases and age-related kidney conditions.This knowledge may provide new insights and theoretical support for the prevention and treatment of kidney diseases.
