The Role of Complement C3 and Its Related Signaling Pathways in Pathologic Pain
10.13865/j.cnki.cjbmb.2024.11.1290
- VernacularTitle:补体C3及其相关信号通路在病理性疼痛中的作用
- Author:
Qiu-Mei LIN
1
;
Dong-Mei WANG
1
Author Information
1. 福建师范大学生命科学学院,福建省发育与神经生物学重点实验室,福州 350117
- Publication Type:Journal Article
- Keywords:
complement component 3(C3);
pathologic pain;
janus protein tyrosine kinase 2(JAK2)/signal transduction and activator of transcription 3(STAT3);
nuclear factor-kappa B(NF-κB);
comple-ment inhibitor
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(2):219-229
- CountryChina
- Language:Chinese
-
Abstract:
The complement system plays an important role in identifying and eliminating pathogens,clearing physiological debris,coordinating immune response and homeostasis,etc.As an early warning signal of inflammatory response,abnormal complement activity is an important cause of pathologic pain diseases.Complement 3(C3)is an important indicator of the activation of the complement system during pathologic pain induction.Experimental and clinical epidemiological studies have found abnormal in-crease of C3 in peripheral and central nerve in various types of pathologic pain,and C3 directly or indi-rectly regulates the response of neurons to neuropathy by binding specific C3 receptors.C3 can directly regulate various aspects of neuronal life and death through specific complement receptors expressed on the plasma membrane of neurons,and can also indirectly regulate by recruiting glial cells and immune cells through various mechanisms to transmit complement signals to neurons,which guide the response of neu-rons to tissue injury,neurotrauma,and neuropathy.This article mainly reviews the mechanism of cyto-kines and signaling pathways involved in C3 in pathologic pain,and discusses the possibility of C3 as an analgesic target in pathologic pain.
