Application of Zeolitic Imidazolate Framework-8 in Bone Tissue Regeneration
10.13865/j.cnki.cjbmb.2024.12.1308
- VernacularTitle:沸石咪唑酯骨架-8在骨组织再生中的应用
- Author:
Wei-Qiang HU
1
;
Kai LUO
1
;
Xiong-Cheng XU
1
Author Information
1. 福建省口腔疾病研究重点实验室,福建省口腔生物材料工程技术研究中心,福建医科大学口腔组织工程研究中心,福建医科大学附属口腔医院,福州 350004
- Publication Type:Journal Article
- Keywords:
zeolitic imidazolate framework-8(ZIF-8);
bone regeneration;
osteogenesis;
drug delivery
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(2):210-218
- CountryChina
- Language:Chinese
-
Abstract:
How to effectively achieve regenerative repair of large bone defects remains a significant chal-lenge in current clinical treatment.Traditional bone regeneration materials have yet to yield ideal results,while the emergence of nanomaterials offers new options for bone regeneration.In recent years,metal-or-ganic frameworks(MOFs)have been widely applied in fields such as biomedicine,among which zeolitic imidazolate framework-8 nanoparticles(ZIF-8 NPs)have been extensively studied.ZIF-8 NPs are easy to synthesize,with controllable particle sizes,large specific surface areas,high thermal stability,and pH responsiveness.The nanoscale size of ZIF-8 NPs can be utilized to adjust the mechanical properties of biomaterials,further aligning with the elastic modulus of bone tissue.Additionally,ZIF-8 NPs facilitate osteogenic differentiation,vascular regeneration,and exhibit antibacterial properties,while also serving as carriers for controlled release of drugs or biomacromolecules.This article summarizes the characteris-tics and biocompatibility of ZIF-8 NPs and reviews their application progress in the field of bone tissue re-generation,including the enhancement of mechanical properties,cell adhesion,osteoinductive activity,angiogenic ability,anti-inflammatory ability and antibacterial ability of bone regeneration materials.This review aims to provide references for advancing the preparation and application of ZIF-8-based bioactive materials.
