Advances in the Application of Single-cell Multi-omics Technology in Fat Deposition
10.13865/j.cnki.cjbmb.2024.12.1177
- VernacularTitle:单细胞多组学技术及其在脂肪沉积中应用
- Author:
Yi-Chen LIU
1
;
Ming CHENG
1
;
Rui CAI
1
Author Information
1. 西北农林科技大学动物科技学院,陕西省动物遗传育种与繁殖重点实验室,陕西杨凌 712100
- Publication Type:Journal Article
- Keywords:
single-cell;
multiomics technique;
fat deposition
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(2):201-209
- CountryChina
- Language:Chinese
-
Abstract:
Adipose tissue consists of multiple types of cells with different proliferative capacities,differ-ent directions of differentiation,and different executive functions,so parsing the subcellular types of adi-pose tissue is of great significance in elucidating the molecular mechanisms of the formation of important traits in the organism.In recent years,with the substantial improvement of the sensitivity of scientific in-struments,the continuous improvement of the automation level and precision from sample preparation to data analysis,and the need to improve the resolution of scientific research,scientists have come up with a variety of studies on single cells,and the single-cell multi-omics technology has developed rapidly.Sin-gle-cell multi-omics technology mainly includes single-cell genomics,single-cell transcriptomics,single-cell proteomics and single-cell metabolomics and the joint application of each of them.This technology realizes the ability to reveal the heterogeneity of adipocytes,helps discovering new adipocyte isoforms and exploring the trajectory of adipocyte differentiation at the level of single-cell resolution at different levels of biological processes,and has achieved great breakthrough progress in the field of biology and medicine.Single-cell multi-omics technology has been serving as an entry point for research on the occurrence and development of many diseases and accelerating the development of key emerging technologies such as gene editing and stem cell breeding.In this paper,we summarize the types of single-cell multi-omics technology and its characteristics,review the progress of the application of this technology in the deposi-tion of intramuscular,intermuscular,subcutaneous and visceral adipose tissues,and discuss its prospects and challenges.This review aims to demonstrate the important role of this technology in the study of adi-pose deposition,and provide theoretical basis for the analysis of the trait formation mechanism and the treatment of metabolic disorders,such as obesity,in human beings.
