Study on the correlation between myocardial fibrosis and heart failure severity in patients with heart failure via cardiac MR
10.3969/j.issn.1002-1671.2025.02.011
- VernacularTitle:心脏MR评估心衰患者心肌纤维化与心衰严重程度的相关性研究
- Author:
Ping CUI
1
;
Song WANG
1
;
Jinxiang XIA
1
;
Hu LIAN
1
;
Hui WU
1
;
Xing ZHONG
1
;
Chuanmin LI
1
;
Sutong WU
1
Author Information
1. 合肥市第二人民医院影像中心,安徽 合肥 230012
- Publication Type:Journal Article
- Keywords:
heart failure;
late gadolinium enhancement;
T1 mapping;
myocardial fibrosis
- From:
Journal of Practical Radiology
2025;41(2):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between myocardial fibrosis(MF)and left ventricular ejection fraction(LVEF)and myocardial injury markers in heart failure patients via cardiac magnetic resonance(CMR).Methods Seventy-six patients with heart failure were selected,including 32 cases of heart failure with preserved ejection fraction(HFpEF)(HFpEF group),15 cases of heart failure with mid-range ejection fraction(HFmEF)(HFmEF group),and 29 patients of heart failure with reduced ejection fraction(HFrEF)(HFrEF group).Additionally,7 healthy individuals undergoing physical examinations were included(control group).CMR parameters and biological markers for the heart failure groups were collected for all subjects.The differences in native T1 value and extracellular volume fraction(ECV)between the heart failure group and the control group were compared,respectively.The differences in native T1 value,ECV,late gadolinium enhancement(LGE)score,serum creatine kinase-MB(CK-MB),cardiac troponin Ⅰ knockdown(cTnI-KD),and N-terminal pro-brain natriuretic peptide(NT-proBNP)among heart failure subgroups were also compared,respectively.Spearman correlation analysis was used to examine the relationships between MF imaging indicators and LVEF,as well as NT-proBNP levels.Results The differences in native T1 value,ECV,LGE score,and NT-proBNP between the heart failure group and the control group,as well as between the heart failure subgroups were statistically significant(P＜0.05).The native T1 value,ECV,and LGE score in the heart failure group were positively correlated with NT-proBNP,and negatively correlated with LVEF.Conclusion The native T1 value,ECV value and LGE score are correlated with heart failure severity.CMR can detect myocardial injury early in patients with HFpEF and provide valuable information for risk stratification of MF.
