Comparative analysis of imaging and pathological features of pulmonary cryptococcosis in non-immunosuppressed patients
10.3969/j.issn.1002-1671.2025.02.009
- VernacularTitle:非免疫抑制患者肺隐球菌病影像与病理特征对比分析
- Author:
Shihao CHEN
1
;
Gen XU
;
Yulin TANG
;
Jin'e ZHANG
;
Yufa LI
Author Information
1. 平江县第一人民医院放射科,湖南 岳阳 414500
- Publication Type:Journal Article
- Keywords:
pulmonary cryptococcosis;
non-immunosuppressive;
computed tomography;
pathology
- From:
Journal of Practical Radiology
2025;41(2):217-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the imaging and pathological features of pulmonary cryptococcosis(PC)in non-immunosuppressed patients.Methods A total of 56 non-immunosuppressed patients pathologically confirmed as PC were analyzed retrospectively,and the signs included halo sign,bronchial distension sign,superficial lobulation sign,and nodule accumulation,fusion sign were compared with the pathological features.Results CT images showed that the lesions of all 56 cases were located within 15 mm below the pleura.Distribution of the lesions were as follows:48 cases were located in unilateral lung(85.7％),8 cases in bilateral lungs(14.3％);47 cases were located in the lower lobes of the lungs(83.9％).Features of lesion morphology were as follows:48 cases were nodule/mass lesions(85.7％);6 cases were mixed lesions(10.7％);and 2 cases were solid infiltrates lesions(3.6％).Features of imaging signs were as follows:halo sign was in 46 cases(82.1％),bronchial distension sign in 31 cases(55.3％),superficial lobulation sign in 31 cases(55.3％),nodule accumulation,fusion sign in 26 cases(46.4％),burr sign in 14 cases(25.0％),cavity in 12 cases(21.4％);small amount of pleural effusion on the affected side in 5 cases(8.9％);and no enlarged lymph nodes were detected in the mediastinum.In 56 patients with PC,granulomatous inflammation pathologically characterized by multinucleated giant cells,epithelioid cell-like hyperplasia,and lymphocytic infiltration was predominantly identified in the nodule/mass lesions(45 cases),whereas pathologically non-granulomatous inflammation(lymphocytic infiltration/coagulative necrosis)was less identified.Conclusion In the non-immunosuppressed population,PC has more characteristic imaging and pathological manifestations,with predominantly nodule/mass on imaging,accompanied by halo sign,bronchial distension sign,superficial lobulation sign and nodule accumulation,fusion sign,etc.Pathologically,PC is mainly characterized by granulomatous inflammation,and the recognition of these signs is helpful in improving the conformity rate of the diagnostic imaging of this disease.
