Cross-regulation Between Protein Acylation and Cancer Cell Metabolism
10.13865/j.cnki.cjbmb.2024.11.1324
- VernacularTitle:蛋白质酰基化修饰与癌细胞代谢的双向调控
- Author:
Yu-Xin LAI
1
;
Zi-Jun PENG
1
;
Jing LIANG
1
Author Information
1. 北京大学基础医学院,生物化学与分子生物学系,北京 100191
- Publication Type:Journal Article
- Keywords:
lactylation;
succinylation;
crotonylation;
cancer metabolism
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(2):169-177
- CountryChina
- Language:Chinese
-
Abstract:
Protein acylation is a group of recently identified chemical modification closely linked to me-tabolism with the metabolic intermediate acyl-coenzyme A(acyl-coA)as the substrate.Acylation posses-ses similar chemical structures to acetylation,with differences in carbon chain length,hydrophobicity,and charge.Most acyl-CoAs are intermediate metabolites,the level of which are influenced by the intra-cellular metabolic state.Therefore,protein acylation is greatly affected by cellular metabolism.Metabolic reprogramming is an important feature of tumor cells.In addition to the classic"Warburg effect",cancer cells exhibit abnormal regulation in lipid metabolism,amino acid metabolism and biological oxidation.Acylation on histones can impact chromatin structure,regulating gene expression and DNA repair critical-ly involved in cancer progression.On the other hand,acylation on non-histones can regulate signal trans-duction,enzymatic activity,or protein-protein interactions to affect cancer cell behaviors such as prolifer-ation,invasion,immune evasion,and vascular remodeling.Focusing on three types of acylation closely related to metabolism:lactylation,succinylation,and crotonylation,this article introduces the produc-tion,raw materials,regulatory mechanism and factors of protein acylation.We then review representative studies to show how cancer cell metabolic reprogramming can regulate these processes and histone/non-histone acylation levels,which subsequently affect the expression and function metabolism-related genes/proteins to form a bidirectional dialogue and accelerate cancer progression.In addition,we present sever-al prospects for potential research directions and translational applications in the field.
