Rethinking lymph node dissection in gastric cancer during the era of immunotherapy
10.3760/cma.j.cn441530-20250626-00242
- VernacularTitle:免疫治疗时代胃癌淋巴结清扫再思考：向精准化与功能保留迈进
- Author:
Jie CHEN
1
;
Yingjie WU
;
Fenglin LIU
Author Information
1. 复旦大学附属肿瘤医院胃外二科 复旦大学上海医学院肿瘤学系，上海 200032
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Immunotherapy;
Neoadjuvant therapy;
Lymphadenectomy
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(9):960-963
- CountryChina
- Language:Chinese
-
Abstract:
The rapid development of immunotherapy has changed the treatment pattern of gastric cancer surgery, constantly advancing from the battlefield of advanced gastric cancer treatment to neoadjuvant therapy. The combination of immunotherapy and chemotherapy has become a new trend in the treatment of locally advanced gastric cancer. This change has prompted us to re-examine the concept of traditional radical surgery for gastric cancer, especially for lymph node dissection, it presents new challenges. As the core site of immune response, lymph node dissection strategy has become one of the key factors affecting the overall efficacy of gastric cancer, and it urgently needs to be re optimized and evaluated in the wave of immunotherapy. Thus, a more precise and personalized new paradigm for radical gastric cancer surgery can be established, ultimately achieving multiple improvements in short-term and long-term efficacy, as well as quality of life.
