Association between circadian syndrome, metabolic syndrome and mild cognitive impairment in older adults
10.3760/cma.j.cn371468-20241021-00496
- VernacularTitle:老年人昼夜节律综合征和代谢综合征与轻度认知障碍的关联研究
- Author:
Jie LU
1
;
Rui LIU
;
Shi TANG
;
Tingting HOU
;
Lin CONG
;
Yongxiang WANG
;
Yifeng DU
Author Information
1. 山东第一医科大学附属省立医院神经内科，济南 250021
- Publication Type:Journal Article
- Keywords:
Circadian syndrome;
Metabolic syndrome;
Mild cognitive impairment;
Sleep duration;
Depressive symptoms
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2025;34(3):208-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between circadian syndrome (CircS), metabolic syndrome (MetS) and mild cognitive impairment (MCI) in elderly rural adults in China.Methods:From March to September 2018, totally 5 765 participants aged 60 years or older from 52 villages in Yanlou Town, Yanggu County, Shandong Province were selected. The data included demographic, underlying disease and neuropsychological data were collected by questionaire survey. Having ≥3 of the following components was defined as MetS: elevated waist circumference, high triglycerides, low high-density lipoprotein cholesterol, elevated blood pressure and elevated fasting glucose. Having ≥4 of the following components was defined as CircS: short sleep (<6 h/d), depression and five other components which were used to define MetS, with elevated waist circumference as a mandatory item. MCI was diagnosed according to Petersen's criteria and further classified into amnestic MCI (aMCI) and non-amnestic MCI (naMCI) based on whether the memory domains impaired.Data were analyzed using multivariable Logistic regression and general linear regression models by R statistical software.Results:In the total sample ( n=4 898), 1 280 participants were diagnosed with MCI, of which 1 075 were aMCI and 205 were naMCI.Compared to the normal group, CircS alone was significantly associated with increased risks of MCI ( B=0.695, P=0.039) and aMCI ( B=0.782, P=0.024), as well as lower verbal fluency scores ( B=-0.244, P=0.045). No significant associations were found between MetS alone or both MetS and CircS and cognitive impairment( P>0.05). At the component level, short sleep and depression were associated with increased risks of MCI ( B=0.167, P=0.025; B=0.605, P<0.001) and aMCI ( B=0.185, P=0.020; B=0.600, P<0.001). Conclusion:Individuals with CircS are at a higher risk of cognitive impairment, CircS is more strongly associated with cognitive impairment than MetS, with short sleep duration and depressive symptoms potentially playing key roles.
