Extrachromosomal Circular DNA in the Tumor Research Progress and Clinical Application Prospects
10.13865/j.cnki.cjbmb.2024.11.1273
- VernacularTitle:染色体外环状DNA在肿瘤中的研究进展与临床应用展望
- Author:
Jia-Qi LIANG
1
;
Jin-Qian LI
;
Tong OU
Author Information
1. 汕头大学医学院罗湖临床学院医学中心,广东 深圳 518000;深圳市罗湖医院集团医学检验实验室,广东 深圳 518000
- Publication Type:Journal Article
- Keywords:
extrachromosomal circular DNA(eccDNA);
cancer;
oncogene;
liquid biopsy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(1):68-78
- CountryChina
- Language:Chinese
-
Abstract:
Extrachromosomal circular DNA(eccDNA)is a special kind of circular DNA molecules in nucleus of eukaryotes.These molecules are derived from chromosome genomes,and can independently participate in a variety of cell physiological or pathological processes,which are closely associated with the occurrence and development of tumors.The discovery of eccDNA can be traced back to the 1970s,and with the development of molecular biology technology,researchers have gradually revealed its impor-tant function in cancer.The formation of eccDNA is a complex process involving multiple mechanisms,including breakage-fusion-bridge cycle,chromothripsis,translocation-deletion-amplification,episome model and fork stalling and template switching,etc.eccDNA,especially large molecular weight eccDNA(＞1 Mb,also known as ecDNA),plays an important role in promoting the amplification and activation of oncogenes,driving tumor heterogeneity and drug resistance,and has shown broad application potential as a molecular marker for tumor liquid biopsy.This review summarizes the exploration history,biogenesis,functions in tumor biology and detection,specificity in different types of tumors and analysis methods of eccDNA,and also discusses its application value in clinical diagnosis and treatment of tumors,so as to provide reference for further exploration of eccDNA in basic research and clinical practice of tumors.
