Venous phase CT radiomics for diagnosing colorectal cancer complicated with tumor deposit and/or lymph node metastasis
10.13929/j.issn.1672-8475.2025.09.008
- VernacularTitle:静脉期CT影像组学诊断结直肠癌伴肿瘤沉积和/或淋巴结转移
- Author:
Yue TENG
1
;
Wang CHEN
1
;
Yuan XU
1
Author Information
1. 南京大学医学院附属盐城第一医院(盐城市第一人民医院)影像科,江苏 盐城 224000
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
extranodal extension;
lymphatic metastasis;
tomography,X-ray computed;
radiomics
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(9):594-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of venous phase CT radiomics for diagnosing colorectal cancer(CRC)complicated with tumor deposit(TD)and/or lymph node metastasis(LNM).Methods Totally 263 CRC patients were retrospectively enrolled and divided into TD(+)LNM(+)group(group A,n=103),TD(+)LNM(-)group(group B,n=63)and TD(-)LNM(+)group(group C,n=97)based on pathological results,also randomly divided into training set(n=210)and test set(n=53)at the ratio of 8∶2.Radiomics features of CRC were screened based on venous phase CT images.Radiomics models were constructed with support vector machine(SVM),multilayer perceptron(MLP)and K-nearest neighbor(KNN),respectively,and their diagnostic efficacy were analyzed.Results In both training set and test set,SVM model had the highest overall efficacy for diagnosing CRC complicated with TD and/or LNM.Due to the uneven distribution of sample sizes among 3 groups,DeLong test was performed on the micro-averaged area under the curve(Micro AUC),which was more robust for handling class imbalance problems.In training set,significant differences were found between SVM and MLP models,as well as between SVM and KNN models(both P＜0.05),while in test set,significant differences were observed between each 2 models(all P＜0.05).Conclusion Venous phase CT radiomics models,especially SVM model was helpful for diagnosing CRC complicated with TD and/or LNM.
