Influencing factor of prognosis of symptomatic intracranial large artery occlusive cerebral infarction in nonacute phase
10.3969/j.issn.1004-1648.2025.01.002
- VernacularTitle:非急性期症状性颅内大动脉闭塞脑梗死预后的影响因素
- Author:
Yongmei ZHANG
1
;
Yating WANG
;
Tiantian HU
Author Information
1. 453000 新乡市中心医院远程医学中心
- Publication Type:Journal Article
- Keywords:
symptomatic intracranial large artery occlusion cerebral infarction in the non-acute phase;
prognosis;
endovascular opening therapy;
nomogram
- From:
Journal of Clinical Neurology
2025;38(1):11-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factor of prognosis of symptomatic intracranial large artery occlusive(ILAO)cerebral infarction in nonacute phase.Methods According to the prognosis,86 patients with symptomatic ILAO cerebral infarction in nonacute phase were divided into good prognosis group and poor prognosis group,and the clinical data of the two groups were compared.Multifactorial Logistic regression analysis was used to screen out the factors that influence prognosis.The related factors were combined to construct a nomogram for predicting poor prognosis of ILAO cerebral infarction in nonacute phase,validated by calibration curves and decision curve analysis.Results Compared with those in the good prognosis group,age,admission mRS,admission NIHSS score,globulin level and medication ratio in the poor prognosis group were significantly higher,and triacylglycerol level,albumin-globulin ratio in the poor prognosis group were significantly lower(P＜0.05-0.01).Multifactorial Logistic regression analysis showed that admission mRS was positively associated with poor 3-month prognosis of patients with ILAO cerebral infarction in nonacute phase(OR=2.551,95％CI:1.134-5.738,P=0.024);endovascular opening therapy was negatively associated with poor 3-month prognosis of patients with ILAO cerebral infarction in the nonacute phase(OR=0.132,95％CI:0.027-0.634,P=0.011).Incorporating admission mRS and endovascular opening treatment to establish a nomogram had good predictive efficacy.Conclusions Admission mRS and endovascular recanalization treatment increased and decreased the risk of poor prognosis at 3 months in patients with ILAO cerebral infarction in nonacute phase,respectively.The nomogram established by combining the two has good application value in predicting the poor prognosis of patients.
