Research progress on therapeutic effect of neuronal pentraxin 2 in neurodegenerative diseases
10.3969/j.issn.1004-1648.2025.01.018
- VernacularTitle:神经元正五聚蛋白2在神经退行性疾病治疗作用中的研究进展
- Author:
Jianan ZHANG
1
;
Yipeng JIANG
;
Li CAO
Author Information
1. 730000 兰州甘肃中医药大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
neuron pentameric protein 2;
neurodegenerative disease;
research progress
- From:
Journal of Clinical Neurology
2025;38(1):74-77
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are a group of disorders characterized by progressive and chronic degeneration of neurons in the central or peripheral nervous system,primarily including conditions such as amyotrophic lateral sclerosis,frontotemporal dementia,Alzheimer's disease,Parkinson's disease,multiple sclerosis,Huntington's disease and age-related macular degeneration.The condition worsens over time,ultimately leading to neuronal loss and synaptic dysfunction.Despite significant advances in medical research,the diagnosis and treatment of neurodegenerative diseases still face major challenges.There is an urgent need for effective and innovative treatment strategies as well as early monitoring methods.This involves not only new drug targets but also research into disease mechanisms.Neuronal pentraxin 2(NPTX2)is a protein expressed in the nervous system,highly expressed in synaptic regions of the brain,where it plays a critical role in synaptic plasticity and the formation and maintenance of neural networks.This paper reviews the role of NPTX2 in neurodegenerative diseases and summarizes recent research progress.
