The effect of triglyceride-glucose index on the severity of depression in patients with depression
10.3760/cma.j.cn371468-20240201-00060
- VernacularTitle:抑郁症患者甘油三酯-葡萄糖指数对抑郁程度的影响
- Author:
Man JIN
1
;
Hao LIANG
;
Xueru ZHANG
;
Shipan ZHANG
;
Chenyang GAO
;
Xiaona CUI
;
Litao LI
;
Peiyuan LYU
Author Information
1. 河北医科大学 河北省人民医院神经内科，河北省脑网络与认知功能重点实验室，石家庄 050051
- Publication Type:Journal Article
- Keywords:
Depression;
Insulin resistance;
Triglyceride-glucose index;
Severity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(12):1106-1110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of triglyceride-glucose index (TyG) on the severity of depression in patients with depression.Methods:The clinical data of 653 patients with depression admitted to Hebei General Hospital from January to December 2021 were retrospectively analyzed. The patients were categorized into mild-moderate depression group ( n=324) and severe depression group ( n=329) according to the 17-item Hamilton depression scale (HAMD-17) score. Patients' demographics and data on fasting plasma glucose (FPG), triglyceride (TG), total cholesterol, high-density lipoprotein, and low-density lipoprotein were extracted from the electronic medical records, and TyG was calculated. Statistical analyses were performed by SPSS 25.0 software.The Mann-Whitney U test was used to compare the differences between the two groups. Spearman correlation analysis and binary Logistic regression analysis were used to investigate the relationship between TyG level and depression severity. Results:(1) In the severe depression group, FPG( 956.9 (118.9) mg/L vs 865.0 (1 44.2) mg/L), TG(1 275.8 (1 027.8) mg/L vs 983.5 (766.4) mg/L), total cholesterol (2 007.0 (477.6) mg/L vs 1 730.5 (547.2) mg/L), high-density lipoprotein (514.3 (168.2) mg/L vs 464.0 (138.2) mg/L), low-density lipoprotein (1 264.5 (326.8) mg/L vs 1 088.6 (412.8) mg/L), and TyG (8.72 (0.77) vs 8.37 (0.78)) were higher than those in the mild-moderate depression group, and the differences were statistically significant (all P<0.05).(2) Both TyG level and HAMA score were positively correlated with HAMD-17 score ( r=0.231, 0.586, both P<0.05); (3) The results of binary logistic regression analysis showed that TyG ( B=1.116, OR=3.054, 95% CI=2.058-4.531, P<0.05) was a risk factor for the severity of depression in patients with depression. Conclusion:The higher the TyG, the more severe the severity of depression in patients. Insulin resistance may affect the severity of depression in patients with depression.
