Research progress in identification methods andtheir delivery systems of novel epitopes
10.16303/j.cnki.1005-4545.2025.02.27
- VernacularTitle:抗原表位鉴定的新方法及其递送系统的研究进展
- Author:
Yuxuan GAO
1
;
Huanjie ZHAI
1
;
Xin SONG
1
;
Shuwen LI
1
;
Huaji QIU
1
;
Yongfeng LI
1
Author Information
1. 中国农业科学院 哈尔滨兽医研究所 动物疫病防控全国重点实验室,黑龙江哈尔滨 150069
- Publication Type:Journal Article
- Keywords:
epitope vaccine;
B cell epitope;
T cell epitope;
delivery system
- From:
Chinese Journal of Veterinary Science
2025;45(2):389-396
- CountryChina
- Language:Chinese
-
Abstract:
Epitope vaccine is a novel strategy for vaccine development in recent years,exhibiting ad-vantages such as safety,and the ability to induce specific humoral and cellular immune responses a-gainst pathogens.Among them,the identification and delivery of epitopes are crucial in the design of multi-epitope vaccines.Compared to traditional methods of antigenic epitope identification,vari-ous new techniques such as bioinformatics,ELIspot,and intracellular cytokine staining have been developed.Since the direct immunization of multi-epitope peptides results in low protective effica-cy,efficient delivery systems are urgently needed.The antigenic epitopes commonly used delivery systems include viral vectors,and non-virus vectors such as nanoparticles,etc.Additionally,to en-hance the immunization efficacy of vaccines,antigenic epitopes are usually modified,including mul-tiple epitopes in tandem and epitope targeting modification and other strategies.This review sum-marizes the methods for accurate identification of antigenic epitopes with well immunogenicity as well as effective delivery strategies for antigenic epitopes,providing new insight into the develop-ment of novel multi-epitope vaccines.
