Probiotics empower postoperative intestinal function recovery after colorectal surgery: mechanisms and clinical progress
10.3760/cma.j.cn441530-20250310-00093
- VernacularTitle:益生菌助力结直肠术后肠道功能恢复的机制与临床应用进展
- Author:
Peng LAI
1
;
Zhen HE
1
Author Information
1. 中山大学附属第六医院普通外科（结直肠外科）人体微生态与老年慢性疾病教育部重点实验室 广州市黄埔区中六生物医学创新研究院，广州 510655
- Publication Type:Journal Article
- Keywords:
Probiotics;
Colorectal surgery;
Intestinal function recovery;
ERAS;
Mechanism;
Clinical application
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(6):619-626
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal dysfunction is a common and significant complication in colorectal surgical practice, which is associated with gut microbiota dysbiosis caused by various perioperative interventions. Currently, enhanced recovery after surgery (ERAS) protocols have been increasingly adopted in clinical practice, greatly accelerating the recovery of postoperative intestinal function. However, there are still no effective interventions in the ERAS protocols to target surgery-induced gut microbiota dysbiosis. Probiotics, as a key treatment method targeting the gut microbiota, can stimulate intestinal motility, inhibit the colonization of pathogenic bacteria, enhance intestinal barrier function, among other effects. Based on these effects of probiotics, they are expected to resolve the neglected gut microbiota dysbiosis, further accelerating the postoperative recovery of intestinal function after colorectal surgery. This article reviews the mechanisms and clinical progress in postoperative bowel functional recovery after colorectal surgery.
