Role of innate immune cells in the immune and inflammatory mechanisms of abdominal aortic aneurysm:a research progress review
10.7659/j.issn.1005-6947.2024.12.018
- VernacularTitle:固有免疫细胞参与腹主动脉瘤免疫与炎性机制的研究进展
- Author:
Xianlu MA
1
;
Tianming WANG
;
Peixi ZHANG
;
Yongjie ZHAO
;
Huifeng SHI
Author Information
1. 山东省济宁市第一人民医院心脏大血管外科,山东济宁 272011;福建医科大学省立临床医学院,福建福州 350001
- Publication Type:Journal Article
- Keywords:
Aortic Aneurysm,Abdominal;
Immunity;
Inflammation;
Cytokines;
Review
- From:
Chinese Journal of General Surgery
2024;33(12):2083-2090
- CountryChina
- Language:Chinese
-
Abstract:
Abdominal aortic aneurysm (AAA) is a life-threatening large-vessel disease closely associated with immune and inflammation-related mechanisms. During the development of AAA,innate immune cells play a pivotal role in the immune-mediated inflammatory infiltration and destruction of the aortic wall. These cells include neutrophils,monocytes,macrophages,dendritic cells,mast cells,natural killer cells,innate lymphoid cells,and invariant natural killer T cells. Although various immune cells have been progressively identified in the study of AAA,their activation mechanisms and functions remain to be further elucidated. This article summarizes the roles of innate immune cells in the progression of AAA and discusses the regulatory mechanisms of their activation in this disease,providing a theoretical basis for research on AAA progression.
