Selection and research advances of intraperitoneal drug treatment for colorectal peritoneal metastasis
10.3760/cma.j.cn441530-20250110-00018
- VernacularTitle:结直肠癌腹膜转移腹腔药物治疗的研究进展
- Author:
Xiaoyan HUANG
1
;
Jingwen XIE
;
Xiusen QIN
;
Yuanxin ZHANG
;
Rui LUO
;
Huabin HU
;
Junwen YE
;
Huaiming WANG
;
Lili CHU
;
Rongkang HUANG
;
Hui WANG
;
Xiaoyan LI
Author Information
1. 中山大学附属第六医院药学部，广州 510655
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Peritoneal metastasis;
Intraperitoneal drug therapy;
Intraperitoneal chemotherapy;
Intraperitoneal biological therapies
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(5):564-573
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal metastasis is a common form of distant metastasis in patients with colorectal cancer, and it is typically associated with a poor prognosis. The development of peritoneal metastasis involves complex molecular mechanisms and multifactorial regulation of the tumor microenvironment. Due to the presence of the blood-peritoneal barrier, only a small amount of systemic medication reaches the peritoneal cavity, resulting in limited efficacy against peritoneal metastasis. Intraperitoneal administration shows significant therapeutic advantages as it can directly target the tumor microenvironment, maintain high local drug concentrations, and reduce systemic toxicity. Intraperitoneal chemotherapy, especially hyperthermic intraperitoneal chemotherapy, has become a cornerstone therapeutic strategy in the clinical treatment of peritoneal metastasis. When selecting chemotherapy drugs and drug combinations, pharmacokinetic properties, efficacy, and safety must be comprehensively considered to optimize the treatment outcomes. In addition, the unique microenvironment of the peritoneal cavity provides new treatment approaches for biological treatment strategies, including antitoxins, vaccines, immune checkpoint inhibitors, etc. Techniques such as pressurized intraperitoneal aerosol chemotherapy and novel drug delivery systems demonstrate potential for enhanced efficacy, offering promising alternatives to improve patient outcomes. This article will review peritoneal barrier characteristics, intraperitoneal drug transport, intraperitoneal chemotherapy, and intraperitoneal biological therapies, thereby establishing a theoretical framework for precision therapy in colorectal cancer peritoneal metastasis.
