Expression and Significance of MUC6 in Reflux Esophagitis
10.3969/j.issn.1008-7125.2024.11.006
- VernacularTitle:MUC6在反流性食管炎中的表达和意义
- Author:
Xue JIA
1
;
Haiqing HU
1
Author Information
1. 北京大学肿瘤医院内蒙古医院(内蒙古医科大学附属肿瘤医院)内镜中心(010000)
- Publication Type:Journal Article
- Keywords:
Reflux Esophagitis;
Mucin 6;
Immunohistochemistry
- From:
Chinese Journal of Gastroenterology
2024;29(11):677-681
- CountryChina
- Language:Chinese
-
Abstract:
Background:Aberrant expression of mucin 6(MUC6)is involved in multiple inflammatory diseases and cancers.Investigation on the role of MUC6 in reflux esophagitis(RE)is of great importance for early diagnosis and treatment of the disease.Aims:To investigate the relationship between MUC6 and RE,so as to provide theoretical basis for the early diagnosis and treatment of RE.Methods:Expression of MUC6 in normal gastroesophageal junction(GEJ)tissue,and GEJ tissues in mild-to-moderate RE(LA-A/B)and severe RE(LA-C/D),as well as in non-,low-,and high-grade intraepithelial neoplasia(non-GIN,LGIN and HGIN)was detected by immunohistochemistry.The relationship between MUC and the clinical futures of RE was analyzed.Results:MUC6 mainly expressed in the cell membrane and cytoplasm.Its expression was negative or weakly positive in normal GEJ tissue(20％,2/10)and strongly positive in GEJ tissues of RE patients(100％,25/25).MUC expression was not correlated with the gender,age,body mass index and Barrett esophagus(all P＞0.05).Significant correlations were observed between MUC6 expression and the hiatal hernia(HH;non-HH,HH＜3 cm and ≥3 cm in diameter),severity of RE(normal GEJ,mild-to-moderate RE,and severe RE),and intraepithelial neoplasia(non-GIN,LGIN,and HGIN)(all P＜0.05).Conclusions:MUC6 is positively correlated with the severity of RE.
