Application of microecological preparations in patients with chronic kidney disease
10.3760/cma.j.cn115822-20240305-00040
- VernacularTitle:微生态制剂在慢性肾脏病患者中的应用
- Author:
Min LU
1
;
Xiaofang YU
1
Author Information
1. 复旦大学附属中山医院肾内科 上海市肾病与透析研究所 上海市肾脏疾病与血液净化重点实验室 上海市肾脏疾病临床医学中心，上海 200032
- Publication Type:Journal Article
- Keywords:
Chronic kidney disease;
Microecological preparations;
Probiotics;
Prebiotics;
Synbiotics;
Gut flora
- From:
Chinese Journal of Clinical Nutrition
2025;33(2):153-160
- CountryChina
- Language:Chinese
-
Abstract:
Uremic toxin accumulation is the main factor that aggravates renal injury and increases complication risks in patients with chronic kidney disease (CKD). While renal replacement therapy such as hemodialysis and peritoneal dialysis are the mainstay of treatment for uremia, they have a limited role in clearing enterogenous uremic toxins, which are produced by gut flora catabolizing food nutrients. Gut flora dysbiosis is one of the common complications in CKD patients. As microecological preparations, probiotics, prebiotics and synbiotics can improve the clinical symptoms and quality of life in such patients through regulating the imbalance of gut flora. This article reviews the recent progress on the roles and mechanisms of these microecological preparations in patients with CKD.
