Prospects for the treatment of malignant intestinal obstruction associated with peritoneal metastasis in colorectal cancer
10.3760/cma.j.cn441530-20250103-00007
- VernacularTitle:结直肠癌腹膜转移相关恶性肠梗阻的治疗
- Author:
Ziqiang CHU
1
;
Rongkang HUANG
1
;
Xiusen QIN
1
;
Hui WANG
1
Author Information
1. 中山大学附属第六医院普通外科（结直肠外科）广东省结直肠盆底疾病研究重点实验室 广州市黄埔区中六生物医学创新研究院 广东省生物医用材料转化与评估工程技术中心，广州 510655
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Peritoneal metastasis;
Malignant intestinal obstruction;
Treatment
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(5):514-520
- CountryChina
- Language:Chinese
-
Abstract:
Malignant intestinal obstruction is one of the common clinical symptoms of peritoneal metastasis of colorectal cancer, and its pathophysiological mechanism involves various factors such as local invasion and compression of tumors, intestinal adhesions caused by the formation of scattered nodules in the abdominal cavity, inflammatory response in the abdominal cavity, and neuromodulation disorders. Patients with traditional intestinal obstruction are generally treated with surgery, but patients with malignant intestinal obstruction associated with peritoneal metastasis of colorectal cancer can present with multi-level obstruction, complex and diverse symptoms. Combined with multiple metastases in the abdominal cavity and even accompanied by cachexia, malignant intestinal obstruction as a major treatment problem in the field of colorectal surgery is often difficult to be treated by surgery. What's more, it is worth noting that new progress and breakthroughs have been made in the diagnosis and treatment of peritoneal metastasis of colorectal cancer, and the treatment of cancerous intestinal obstruction has also begun to receive extensive attention. Therefore, this article summarizes the clinical features of peritoneal metastasis-related malignant intestinal obstruction in colorectal cancer and looks forward to its treatment challenges.
