Pressurized intraperitoneal aerosol chemotherapy in the treatment of peritoneal metastases from gastrointestinal cancers
10.3760/cma.j.cn441530-20250311-00096
- VernacularTitle:加压腹腔气溶胶化疗在胃肠道肿瘤腹膜转移中的应用
- Author:
Zifeng YANG
1
;
Ruijian CHEN
;
Renjie LI
;
Yong LI
Author Information
1. 南方医科大学附属广东省人民医院（广东省医学科学院）胃肠外科，广州 510080
- Publication Type:Journal Article
- Keywords:
Gastrointestinal neoplasms;
Peritoneal metastases;
Pressurized intraperitoneal aerosol chemotherapy (PIPAC)
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(5):497-507
- CountryChina
- Language:Chinese
-
Abstract:
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is an emerging therapeutic modality for peritoneal carcinomatosis. This review aims to evaluate the safety, efficacy, and current clinical application of PIPAC in the treatment of peritoneal metastases originating from gastrointestinal malignancies. This review outlines the technical principles, historical development, procedural steps, commonly used drugs, and administration protocols of PIPAC; analyses the current clinical application status of PIPAC technology; discusses the current challenges and future directions of PIPAC; suggests that PIPAC technology still needs to conduct more high-quality and large-sample clinical trials to further establish the safety and efficacy of PIPAC, optimize its indications and formulate standardized operation specifications. In the future, multi-centre cooperation, multi-disciplinary cooperation, precision medicine strategies and new drug research and development will promote the clinical transformation and standardized application of PIPAC technology.
