Role of intensive insulin pump therapy in type 2 diabetes mellitus patients with diabetic kidney disease
10.3760/cma.j.cn115822-20241220-00237
- VernacularTitle:胰岛素泵强化治疗在2型糖尿病合并糖尿病肾脏疾病中的应用效果分析
- Author:
Wanrong DOU
1
;
Ruixue DUAN
;
Xiaoqin CHEN
;
Yongliang FENG
;
Shiwei LIU
Author Information
1. 山西医科大学公共卫生学院，太原 030001
- Publication Type:Journal Article
- Keywords:
Insulin pump;
Type 2 diabetes mellitus;
Diabetic kidney disease;
Glycemic control;
Renal function
- From:
Chinese Journal of Clinical Nutrition
2025;33(5):364-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of short-term intensive insulin pump therapy on blood glucose control and renal function in type 2 diabetes mellitus (T2DM) patients with diabetic kidney disease (DKD).Methods:The clinical data of 360 T2DM patients with DKD in Shanxi Bethune Hospital from January 2022 to October 2024 were retrospectively analyzed. These patients were divided into an observation group ( n=192; treated with continuous subcutaneous insulin infusion) and a control group ( n=168; treated with conventional hypoglycemic therapy) according to the different treatment modalities; subsequently, 103 pairs of patients entered final analysis by using the propensity score matching method. The differences in glycemic control and improvement of renal function were compared between these two groups. Results:Before the treatment, the blood glucose-, blood glucose fluctuation-, and kidney function-related indicators showed no significant differences between these two groups (all P>0.05). After the treatment, fasting blood glucose, two-hour postprandial blood glucose, and average blood glucose significantly decreased in both groups and were significantly lower in the observation group than in the control group (all P<0.05). In addition, the amplitude of postprandial blood glucose fluctuation, standard deviation of intraday multi-point blood glucose, and difference between the maximum and minimum intraday blood glucose values significantly declined after treatment and were also significantly lower in the observation group than in the control group (all P<0.05). The observation group had a significantly higher total glycemic control rate and a significantly lowr incidence of hypoglycemia (both P<0.05). Finally, the 24-hour urine protein level, serum creatinine level, and urine albumin/creatinine ratio of the observation group significantly dropped after the treatment, and these results were significantly lower than those in the observation group (all P<0.05). Conclusions:Intensive insulin pump therapy benefits T2DM patients with DKD by improving glycemic control and enhancing renal function.
