Natural products regulate oxidative stress in the treatment of spinal cord injury
10.12307/2025.378
- VernacularTitle:天然产物调控氧化应激治疗脊髓损伤
- Author:
Xiaowei ZHANG
1
;
Binghan YAN
;
Daodi QIU
;
Haipeng XUE
;
Guoqing TAN
;
Zhanwang XU
Author Information
1. 山东中医药大学,山东省济南市 250000
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
oxidative stress;
anti-oxidation;
natural products;
natural compounds;
polyphenols;
review
- From:
Chinese Journal of Tissue Engineering Research
2025;29(12):2560-2568
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Spinal cord injury is a serious neurological disease that often results in severe neurological impairment. Oxidative stress is an important link in the pathological process after spinal cord injury,leading to neuronal cell death and loss of function. In recent years,natural products have shown potential application values in the treatment of oxidative stress after spinal cord injury due to their wide range of sources,diverse structures and rich biological activities. OBJECTIVE:To discuss the therapeutic effects of some natural products on oxidative stress after spinal cord injury and the related mechanisms,in order to provide new ideas and directions for antioxidant therapy of spinal cord injury. METHODS:"Spinal cord injury,oxidative stress,anti-oxidation,natural products,natural compounds,polyphenols" were used as the English and Chinese keywords in PubMed,Web of Science,Embase,Cochrane,VIP,CBM,WanFang,and CNKI databases to search relevant articles published from database inception to May 2024. Inclusion and exclusion criteria were developed,and 97 relevant articles were selected by reading titles,abstracts,and full texts. RESULTS AND CONCLUSION:Natural products such as polyphenols can directly scavenge oxidative free radicals by the phenol hydroxyl group in their structure,and alleviate oxidative stress after spinal cord injury. Some natural products can enhance the activity of relevant antioxidant enzymes in vivo and reduce oxidative stress by regulating certain signal transduction pathways. Some natural products can reduce oxidative stress after spinal cord injury by enhancing autophagy. The use of natural products to regulate oxidative stress may become an effective tool for the future clinical treatment of spinal cord injury.
