Role and mechanisms of gut microbiota dysbiosis in the occurrence and development of frailty in older adults
10.3760/cma.j.cn115822-20250508-00082
- VernacularTitle:肠道菌群失调在老年衰弱发生发展中的作用及机制
- Author:
Yonghao LI
1
;
Liru CHEN
;
Huan XI
;
Mingwei ZHU
Author Information
1. 北京医院普通外科肝胆胰外科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Publication Type:Journal Article
- Keywords:
Frailty;
Gut microbiota;
Oral microbiota;
Mechanism;
Metabolites
- From:
Chinese Journal of Clinical Nutrition
2025;33(5):340-346
- CountryChina
- Language:Chinese
-
Abstract:
The high prevalence of frailty in older adults and its close link to adverse outcomes make it a critical public health challenge in the aging global population. Frailty, characterized by multisystem functional decline, significantly increases the risk of falls, disability, and even death, yet its underlying mechanisms remain poorly understood. While the role of gut microbiota as the "second genome" in disease regulation has been widely recognized, its specific mechanisms in the development of frailty syndrome remain to be systematically investigated. This review synthesizes findings from the last decade of international literature to analyze the mechanisms by which gut microbiota dysbiosis contributes to frailty syndrome. We focus on pathways including metabolic disorders, chronic inflammation, oxidative stress, and the oral-gut microbiota axis, aiming to provide insights for clinical diagnosis and treatment.
