Genomic insights into enteral and parenteral nutrition: from bench to bedside
10.3760/cma.j.cn115822-20250711-00137
- VernacularTitle:从基因到营养：肠内与肠外营养中基因组学的转化应用
- Author:
Jingyi MA
1
;
Qiu ZHANG
Author Information
1. 安徽医科大学第一临床医学院，合肥 230032
- Publication Type:Journal Article
- Keywords:
Genomics;
Nutrigenomics;
Enteral nutrition;
Parenteral nutrition;
Precision nutrition
- From:
Chinese Journal of Clinical Nutrition
2025;33(4):315-320
- CountryChina
- Language:Chinese
-
Abstract:
Enteral nutrition (EN) and parenteral nutrition (PN) are the cornerstones of clinical nutritional support, crucial for improving patients' nutritional status and promoting recovery. However, significant variations have been observed in patients' response and tolerance to nutritional support in clinical practice. Some patients even develop serious metabolic complications such as hyperglycemia, hyperlipidemia, and parenteral nutrition-associated liver disease (PNALD). Therefore, the traditional "one-fits-all" strategy can not meet the individual patient needs. Genomics, particularly nutrigenomics, has unveiled the mysteries of nutrient-gene interactions, revealing how genetic background influences an individual's metabolism, absorption, and utilization of nutrients as well as the susceptibility to nutrition-related diseases. This article reviews the role of genomics in EN and PN, exploring its potential to guide individualized nutritional plans for improved efficacy and safety, while also addressing future challenges in precision nutrition therapy.
