Meta-analysis of the correlation between phase angle and sarcopenia and its diagnostic indexes
- VernacularTitle:相位角与肌少症及相关诊断指标的Meta分析
- Author:
Jiayi CHEN
1
;
Huijing LI
;
Yuxuan NONG
;
Yunfang YIN
;
Xiaobo LIU
;
Yue CHEN
;
Xiaoshen HU
;
Dongling ZHONG
;
Juan LI
;
Tianyu LIU
;
Rongjiang JIN
Author Information
- Publication Type:Journal Article
- Keywords: sarcopenia; phase angle; correlation; Meta-analysis; bioelectrical impedance analysis; skeletal muscle mass index; grip strength; gait speed
- From: Chinese Journal of Tissue Engineering Research 2025;29(12):2575-2589
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE:To systematically evaluate the correlation between phase angle and sarcopenia and its diagnostic indexes.METHODS:The PubMed,EMbase,Cochrane Library,Web of Science,CNKI,WanFang Data,VIP and SinoMed databases were electronically searched to collect studies on the correlation between phase angle and sarcopenia and its diagnostic indexes from database inception to May 8,2024. Two reviewers independently screened literature,extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed using RevMan 5.3 and Stata 14.0 software. RESULTS:A total of 50 eligible articles were included. Meta-analysis results showed that compared with the non-sarcopenic population,the phase angle was significantly reduced in sarcopenic patients[standardized mean difference (SMD)=-0.99,95％ confidence interval (CI) (-1.09,-0.90),P<0.00001]. The results of subgroup analysis indicated that the difference of phase angle was more significant in patients with severe sarcopenia and Asian sarcopenia. Moreover,reduction in the phase angle was more obvious in patients with malignant tumors and respiratory diseases with sarcopenia. And skeletal muscle mass index (Pearson's r=0.565,P<0.00001),grip strength (Pearson's r=0.446,P<0.00001),and gait speed (Pearson's r=0.405,P<0.00001) all showed a moderate positive correlation with phase angle. However,appendicular skeletal muscle mass index showed a very weak positive correlation with phase angle (Pearson's r=0.139,P=0.02). CONCLUSION:Phase angle has a significant difference between sarcopenia and non-sarcopenia population,and it is correlated with the diagnostic indexes of sarcopenia to different extents. It suggests that phase angle has some clinical values in the objective diagnosis of sarcopenia. However,the results may be influenced by some factors such as sarcopenia severity and detection instruments of phase angle. Due to the limited quality and quantity of the included studies,more high-quality studies are needed to verify the above conclusion.
