Effects of probiotic supplementation after bariatric surgery on weight loss, glucolipid metabolism, and nutritional status: a Meta-analysis
10.3760/cma.j.cn115822-20240618-00101
- VernacularTitle:减重术后补充益生菌对减重效果、糖脂代谢和营养指标影响的Meta分析
- Author:
Yan WANG
1
;
Xiaobin JIANG
;
Hejia WAN
;
Xueqin XU
Author Information
1. 河南中医药大学医学院，郑州 450046
- Publication Type:Journal Article
- Keywords:
Obesity;
Bariatric surgery;
Probiotic;
Meta-analysis
- From:
Chinese Journal of Clinical Nutrition
2025;33(2):118-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the effects of probiotic supplementation following bariatric surgery on weight loss outcomes, glycemic and lipid metabolism profiles, and nutritional status.Methods:Searches were conducted across China National Knowledge Infrastructure (CNKI), WanFang, VIP, Web of Science, and PubMed using Chinese or English search words including probiotics, morbid obesity, severe obesity, bariatric surgery, sleeve gastrectomy, Roux-en-Y gastric bypass, SG, and RYGB up to May 31, 2024. Meta-analysis was performed using Review Manager 5.3. Study quality was evaluated using Cochrane risk of bias tool.Results:In the 12 randomized controlled trials (RCTs) containing 663 severely obese patients who underwent bariatric surgery, 329 were in the probiotic group (receiving probiotic supplementation following bariatric surgery) and 334 in the control group (using placebo). Compared with the control group, the probiotic group had significantly lower fasting blood glucose ( WMD=-4.42 mg/dL, 95% CI: -7.71–-1.13, P=0.009) and triglyceride ( WMD=-18.75 mg/dL, 95% CI: -35.83–-1.67, P=0.03) and significantly increased vitamin B 12 ( SMD=0.52, 95% CI: 0.02–1.02, P=0.04). However, the two groups showed no significant differences in body mass index, waist circumference, weight, % excess weight loss, hemoglobin A1c, insulin, homeostasis model assessment of insulin resistance, total cholesterol, low-density lipoprotein, high-density lipoprotein, or vitamin D levels (all P>0.05). Conclusion:Supplementing probiotics after bariatric surgery can improve glucose and lipid metabolism and increase vitamin B 12 absorption, whereas its potential effect on weight loss remains unclear.
