Relationship of serum FGF21 and SOST with bone mineral density in menopausal women and their clinical value in predicting osteoporosis
10.3760/cma.j.cn115807-20250117-00031
- VernacularTitle:更年期女性血清FGF21、SOST与骨密度关系及预测骨质疏松症的临床价值
- Author:
Na MA
1
;
Jinzhu GUO
;
Peixing AN
;
Huiya ZHANG
Author Information
1. 西北妇女儿童医院生育健康科，西安 710061
- Publication Type:Journal Article
- Keywords:
Menopause;
Fibroblast growth factor 21;
Osteosclerosis protein;
Bone mineral density;
Osteoporosis
- From:
Chinese Journal of Endocrine Surgery
2025;19(4):574-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of serum FGF21 and SOST with bone mineral density and their predictive value in predicting osteoporosis in menopausal women.Methods:A total of 86 menopausal women who were examined in Northwest Women and Children's Hospital from Jan. 2021 to Jan. 2024 were chosen and separated into osteoporosis group ( n=47) and normal group ( n=39) according to whether they had osteoporosis. Serum fibroblast growth factor 21 (FGF21), osteosclerosis protein (SOST) and bone mineral density (BMD) were measured, and general data such as age, body mass index (BMI), smoking, drinking, hypertension, hyperlipidemia, and diabetes were collected and recorded. The risk factors of osteoporosis in menopausal women were analyzed by logistics regression, and the value of serum FGF21 and SOST levels in predicting osteoporosis in menopausal women was analyzed by receiver operating characteristic (ROC) curve. Results:Serum FGF21 level and bone mineral density T-value in osteoporosis group were lower than those in normal group, while SOST level was higher ( t=5.18,19.30,7.85, P<0.05). Serum FGF21 level was positively correlated with BMD, and serum SOST level was negatively correlated with it ( r=0.476、-0.424, P<0.05). The proportion of smokers and drinkers in osteoporosis group was higher than that in normal group ( χ 2=4.98、5.68, P<0.05). Serum FGF21 level was a protective factor for osteoporosis in menopausal women, and serum SOST level was a risk factor ( OR=0.770,1.194, P<0.05). The area under the curve (AUC) of serum FGF21, SOST and the combination of the two indexes for predicting osteoporosis in menopausal women were 0.800, 0.899 and 0.951, respectively, and the Jordon index were 0.505, 0.723 and 0.787, respectively. Conclusion:Serum FGF21 and SOST levels in menopausal women are correlated with BMD, which has certain predictive value for the occurrence of osteoporosis.
