Correlation of serum SIK2 and RANKL expression levels with osteoporosis in perimenopausal women
10.3760/cma.j.cn115807-20250308-00062
- VernacularTitle:血清SIK2、RANKL表达水平与围绝经期妇女发生骨质疏松的相关性研究
- Author:
Yu LIU
1
;
Qing LIU
;
Hongxia FU
;
Fang WANG
Author Information
1. 天津医科大学第二医院妇科，天津 300211
- Publication Type:Journal Article
- Keywords:
Salt-induced kinase 2;
Receptor activator of nuclear factor κB ligand;
Perimenopausal women;
Osteoporosis
- From:
Chinese Journal of Endocrine Surgery
2025;19(4):569-573
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of serum salt-induced kinase 2 (SIK2) and receptor activator of nuclear factor κB ligand (RANKL) expression levels with osteoporosis in perimenopausal women.Methods:A total of 500 perimenopausal women admitted to the Second Hospital of Tianjin Medical University from Jan. 2023 to Jun. 2023 were studied and separated into osteoporosis group and non-osteoporosis group according to with or without osteoporosis. The general data, serum SIK2 and RANKL expression levels and bone metabolism indexes [type I collagen carboxy peptide (CTX), procollagen I N-Terminal propeptide (PINP), and osteocalcin of N-MID-Osteocalcin (N-MID-OT) ] were compared between the two groups. The correlation of the expression levels of serum SIK2 and RANKL with bone metabolism indexes was analyzed by Pearson correlation; The risk factors of osteoporosis in perimenopausal women were analyzed by Logistic multi-factor model. Results:Of the 500 patients, 88 had osteoporosis (17.6%) ; The serum levels of SIK2 and RANKL, CTX, PINP and N-MID-OT in osteoporosis group were significantly higher than those in non-osteoporosis group ( t=7.53, 13.11, 19.69, 28.79, 26.14, P<0.05). Pearson correlation analysis showed that serum SIK2 and RANKL levels were significantly positively correlated with all indexes of bone metabolism ( r=0.541, 0.480, 0.447; r=0.369, 0.516, 0.482, P<0.05). Logistic regression analysis showed that the number of births, diabetes, SIK2, RANKL and bone metabolism were the factors affecting the incidence of osteoporosis in perimenopausal women ( OR=2.123, 2.243, 3.083, 4.773, 3.789, 2.927, 2.633, P<0.05) . Conclusions:SIK2 and RANKL may be involved in the pathogenesis of osteoporosis by promoting bone turnover imbalance. Together with fertility times, diabetes mellitus and bone metabolism indexes, SIK2 and RANKL are all factors in the development of osteoporosis in perimenopausal women.
